An accurate and precise RP-HPLC method was developed for the simultaneous estimation of metoprolol succinate and telmisartan in tablets. The chromatographic analysis was performed on 4.6´250 mm BDS hypersil C18 HPLC column with 5 mm (particles) packing with mobile phase consisting of acetonitrile and potassium di-hydrogen orthophosphate buffer (pH-3.01) in the ratio 50:50v/v, at a flow rate of 1.0 ml/min and eluents monitored at 225 nm. The retention time for metoprolol succinate was found to be 2.250 and for telmisartan it was found to be 6.397 minutes. The proposed method was simple, accurate and precise and could be successfully employed in routine quality control for the simultaneous estimation of telmisartan and metoprolol succinate in tablet formulation.
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